18.03.2010
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Tamoxifen: Interaction with SSRIs (selective serotonin reuptake inhibitors)
Active substance: tamoxifen
A Canadian cohort study showed that the SSRI, paroxetin, may decrease the effect of tamoxifen in a hormone therapy of mamma carcinoma (BMJ 2010; 340:c693). Concomitant administration of tamoxifen and paroxetin was found to increase breast cancer mortality.
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