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Dear Doctor Letter (Rote-Hand-Brief) on InductOs 1.5 mg/ml powder, solvent and matrix for implantation matrix: Shortage PDF, 72KB, File is accessible Date: 05. November 2015 Topics: Pharmakovigilanz Type: Direct Healthcare Professional Communication

Active substance: dibotermin alfa

The company Medtronic BioPharma B.V. is circulating information that the medicinal product InductOs can currently not be supplied.

Information letter on Zelboraf®: Potentiation of radiation damage PDF, 105KB, File is accessible Date: 20. October 2015 Topics: Pharmakovigilanz Type: Direct Healthcare Professional Communication

Active substance: vemurafenib

The company Roche Pharma AG is circulating information, that cases of severe radiation damage have been reported in patients treated with radiation prior to, during or subsequent to treatment with Zelboraf.

Information Letter on Reminyl®: Serious skin reactions; Stevens-Johnson Syndrome and acute generalised exanthematous pustulosis PDF, 377KB, File is accessible Date: 22. September 2015 Topics: Pharmakovigilanz Type: Direct Healthcare Professional Communication

Active substance: Galantaminhydrobromid

The company Janssen-Cilag is circulating information on a new warning for Reminyl®.

Dear Doctor Letter (Rote-Hand-Brief) on Betmiga® (mirabegron): New recommendations concerning the risk of increased blood pressure PDF, 413KB, File is accessible Date: 07. September 2015 Topics: Pharmakovigilanz Type: Direct Healthcare Professional Communication

Active substance: mirabegron

The company Astellas Pharma GmbH is circulating information that serious cases of hypertension and increased blood pressure have been reported under treatment with mirabegron.

Dear Doctor Letter (Rote-Hand-Brief) on InductOs 1.5 mg/ml powder, solvent and matrix for implantation matrix: Possible temporary shortage of the medicinal product PDF, 77KB, File is accessible Date: 13. August 2015 Topics: Pharmakovigilanz Type: Direct Healthcare Professional Communication

Active substance: dibotermin alfa

The company Medtronic BioPharma B.V. is circulating information that InductOs is expected to run out of stock as of the end of October 2015.

Dear Doctor Letter (Rote-Hand-Brief) on the use of intrauterine devices (IUDs): Risk of uterine perforation PDF, 436KB, File is accessible Date: 23. July 2015 Topics: Pharmakovigilanz Type: Direct Healthcare Professional Communication

Active substance: levonorgestrel

In view of updated results of the "European Active Surveillance Study for Intrauterine Devices” (EURAS-IUD), the company Jenapharm GmbH & Co. KG is circulating information on the investigation of the use of copper-bearing intrauterine …

Information Letter on Dacogen 50 mg, powder for concentrate for solution for infusion: Changes regarding instructions for reconstitution and shelf life PDF, 555KB, File is accessible Date: 10. July 2015 Topics: Pharmakovigilanz Type: Direct Healthcare Professional Communication

Active substance: decitabine

The company Janssen-Cilag GmbH is circulating information on measures to improve stability for reconstitution and shelf life of Dacogen.

Information Letter on SGLT2 inhibitors: Risk of diabetic ketoacidosis PDF, 186KB, File is accessible Date: 10. July 2015 Topics: Pharmakovigilanz Type: Direct Healthcare Professional Communication

Active substance: canagliflozin, capagliflozin, empagliflozin

The companies AstraZeneca AB, Boehringer Ingelheim International GmbH and Janssen-Cilag International N.V. are circulating information on the risk of diabetic ketoacidosis under treatment with SGLT2 inhibitors.

Information letter on Corotrop® 10 mg/10 ml solution for injection: Shortage PDF, 22KB, File is accessible Date: 16. June 2015 Topics: Pharmakovigilanz Type: Direct Healthcare Professional Communication

Active substance: milrinone

The company Sanofi-Aventis Deutschland GmbH is circulating information that the medicinal product Corotrop® 10 mg/10 ml solution for injection is temporarily not available due to capacity issues at the manufacturing site.

Information letter on Kineret® (anakinra) 100 mg and 100 mg/0.67 ml solution for injection in a pre-filled syringe: Visible solid deposits on the surface of the needle PDF, 155KB, File is accessible Date: 16. June 2015 Topics: Pharmakovigilanz Type: Direct Healthcare Professional Communication

Active substance: anakinra

The Swedish company Orphan Biovitrum AB (Sobi) issues information on deposits of the active substance on the surface of the needle.